Joint disease encompasses over 150 conditions and syndromes, which are usually progressive and associated with pain. At any moment, roughly 30% of American adults, or 78 million people are affected by joint pain, swelling, or limitation of movement. Worldwide, 1.7 billion people suffer from joint pain and disease. In many cases, the causes of joint pain are frequently misdiagnosed, leading to unnecessary medical expenses. This creates a tremendous burden on the healthcare system and for patients who must endure pain and activity limitation for a longer period of time without relief. A recent National Ambulatory Medical Care Survey reports that over 84 million office visits are made annually in the US due to joint pain and disease. The economic burden of joint pain on the US economy is estimated at $128 billion annually; $50 billion of which is due to indirect costs such as lost workforce earnings.

These numbers demonstrate a clear need for better tools to aid in the diagnosis of joint pain and disease. A more accurate and rapid diagnosis will lead to more effective treatments and improved life quality for patients.